“It’s all natural, no chemical markers, no electrodes, nothing. If that works out, it could lead to a more natural way to study at least some parts of the brain. They are now adapting their methods to study neurons in the brains of living animals. So far, Palanker, Tong Ling, a postdoctoral fellow and the lead author on the new paper, and colleagues have measured those miniscule shape changes in networks of neuron-like cells in a lab dish. That nanometer-scale change can be measured using optical techniques. The key to the new approach, said Daniel Palanker, a professor of ophthalmology and senior author on the new paper, is that when neurons fire electrical signals they subtly change shape. Daniel Palanker and colleagues developed a way to watch neuron-like cells fire without electrodes or chemical or genetic modifications.
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